gene_symbol
KRAS
hgnc_id
HGNC:6407
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Engineered TCR-T cells recognize KRAS G12D peptide–HLA-A*11:01 on target cells via their TCR and kill them through cytotoxic granule release (perforin/granzymes) and death-receptor signaling.
enzyme_product
On
epitope
On
variant
On
isoform
Off
hla_specific
On
gated
Off
other_modifier
Peptide–MHC I (pMHC) complex; HLA-A*11:01 restriction
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06546150
disease_id_num_tar_ref
1005
drug_id_num_tar_ref
2748