gene_symbol
IL5RA
hgnc_id
HGNC:6017
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Benralizumab binds IL-5Rα on eosinophils/basophils and engages FcγRIIIa on NK cells (enhanced by afucosylation), triggering antibody-dependent cell-mediated cytotoxicity and apoptosis, depleting the target-expressing cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Alpha chain of IL-5 receptor on eosinophils and basophils
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06778746
disease_id_num_tar_ref
1012
drug_id_num_tar_ref
2765