gene_symbol
CD3E
hgnc_id
HGNC:1674
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Glofitamab uses CD3ε on T cells to engage and activate them while binding CD20 on B cells; activated T cells kill CD20+ B cells via perforin/granzyme cytotoxicity. CD3ε-expressing T cells are not the killed cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
T-cell engagement arm; crosslinks T cells to CD20+ B cells to redirect cytotoxicity
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05798156
disease_id_num_tar_ref
1014
drug_id_num_tar_ref
2769