gene_symbol
TUBB
hgnc_id
HGNC:20778
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The ADC binds CD79b on B cells and is internalized; the released MMAE then binds the β-tubulin (vinca) domain to inhibit microtubule polymerization, causing G2/M arrest and apoptosis. β‑tubulin expression alone is not the targeted determinant of killing.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Payload MMAE binds β-tubulin at the vinca site to inhibit microtubule polymerization
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05798156
disease_id_num_tar_ref
1014
drug_id_num_tar_ref
2772