gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Fc-mediated ADCC: trastuzumab binds HER2 on tumor cells and its Fc engages FcγR-bearing effector cells (e.g., NK cells, macrophages) to lyse the target; may also contribute via CDC, while signaling blockade is mainly antiproliferative.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds extracellular domain (domain IV) to inhibit receptor dimerization and signaling
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06886659
disease_id_num_tar_ref
1015
drug_id_num_tar_ref
2773