gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The HER2-targeting ADC binds HER2, is internalized, and releases the DXd topoisomerase I inhibitor, causing DNA damage, cell-cycle arrest, and apoptosis; Fc-mediated ADCC can also contribute, with possible bystander killing.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Receptor tyrosine kinase targeted by trastuzumab; extracellular binding leads to internalization and can mediate ADCC
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05965479
disease_id_num_tar_ref
1024
drug_id_num_tar_ref
2802