gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Vaccine-primed HER2-specific CD8+ T cells recognize HER2 peptides on MHC I and kill HER2+ cells via perforin/granzyme; induced anti-HER2 antibodies can mediate ADCC/complement.
enzyme_product
On
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
ECD/TMD presented by autologous DCs on MHC I/II
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06253494
disease_id_num_tar_ref
1038
drug_id_num_tar_ref
2834