gene_symbol
TNFRSF13C
hgnc_id
HGNC:17755
binding_type
receptor ligand recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
CAR-T cells bind BAFF-R via the BAFF ligand domain of the bicephalic CAR, triggering CD3ζ costimulatory signaling and T-cell–mediated lysis through perforin/granzyme release.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
TNF receptor superfamily; possible/secondary target
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06132711
disease_id_num_tar_ref
1049
drug_id_num_tar_ref
2861