gene_symbol
CD19
hgnc_id
HGNC:1633
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Anti-CD19 CAR T cells bind CD19 on target B cells, triggering T-cell activation (CD28/CD3ζ/TLR2) and delivering cytotoxic effects via perforin/granzyme and Fas–FasL pathways, leading to direct lysis of CD19+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
HLA-independent CAR scFv binding (third-generation 1928T2z)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06486051
disease_id_num_tar_ref
110
drug_id_num_tar_ref
293