gene_symbol
CD3E
hgnc_id
HGNC:1674
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Epcoritamab binds CD3 on T cells to activate and redirect them to CD20+ B cells, which are killed via immune synapse and perforin/granzyme-mediated apoptosis; CD3+ T cells are not the targets of killing.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
T-cell surface antigen; component of TCR-CD3 complex
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05660967
disease_id_num_tar_ref
1078
drug_id_num_tar_ref
2933