gene_symbol
MS4A1
hgnc_id
HGNC:7315
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Epcoritamab crosslinks CD3 on T cells to CD20 on B cells, forming an immune synapse and activating T cells to kill CD20+ cells via perforin/granzyme-mediated apoptosis.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
B-cell surface antigen; tumor-associated antigen on B cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05660967
disease_id_num_tar_ref
1078
drug_id_num_tar_ref
2933