gene_symbol
UNKNOWN
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Autologous TILs recognize tumor-associated peptides on HLA class I via their native TCRs and directly kill target cells through perforin/granzyme- and Fas–FasL-mediated apoptosis, aided by cytokine release.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
Non-mutated overexpressed/lineage antigen peptide–MHC class I complexes on tumor cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06173726
disease_id_num_tar_ref
1087
drug_id_num_tar_ref
2954