gene_symbol
UNKNOWN
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Autologous TILs recognize patient-specific neoantigen peptides presented on HLA class II via their native TCRs and directly kill target cells through cytotoxic degranulation (perforin/granzyme) and Fas–FasL apoptosis, with supportive cytokine effects.
enzyme_product
Off
epitope
On
variant
On
isoform
Off
hla_specific
On
gated
Off
other_modifier
Peptide–MHC class II complexes on tumor cells/antigen-presenting cells recognized by CD4+ TCRs; targets vary per patient
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06173726
disease_id_num_tar_ref
1087
drug_id_num_tar_ref
2954