gene_symbol
UNKNOWN
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
TCR recognition of tumor-associated peptides presented on HLA class II by CD4+ TILs triggers cytotoxic degranulation (perforin/granzymes) and death-receptor pathways, leading to lysis of the presenting cell.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
Non-mutated overexpressed/lineage antigen peptide–MHC class II complexes on tumor cells/APCs
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06173726
disease_id_num_tar_ref
1087
drug_id_num_tar_ref
2954