gene_symbol
SIGLEC2
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
ADC binds CD22, is internalized, and releases calicheamicin that binds DNA and induces double‑strand breaks, triggering apoptosis of CD22+ cells.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Internalization via CD22-mediated endocytosis
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05597085
disease_id_num_tar_ref
1089
drug_id_num_tar_ref
2959