gene_symbol
LGR5
hgnc_id
HGNC:4504
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Petosemtamab binds LGR5 on tumor cells and its IgG1 Fc engages FcγR-expressing effector cells, inducing ADCC (NK cells) and ADCP (macrophages) to deplete LGR5+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
GPCR; extracellular domain binding; cancer stem cell marker
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06525220
disease_id_num_tar_ref
1092
drug_id_num_tar_ref
2964