gene_symbol
CD19
hgnc_id
HGNC:1633
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Anti-CD19 CAR T cells bind CD19 via the CAR (CD28/CD3ζ signaling), activate, and kill the engaged cells through cytotoxic T-cell mechanisms (perforin/granzyme and Fas–FasL). IL-12 secretion enhances this activity.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06343376
disease_id_num_tar_ref
1099
drug_id_num_tar_ref
2996