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eligibility_summary
Adults 18–75 with relapsed/refractory MM or plasma cell leukemia, progressive and measurable (serum/urine M‑protein, sFLC ≥100 mg/L with abnormal ratio, or ≥2% circulating PCs), ECOG 0–1, survival >12 wks, adequate organ function, consent, effective contraception. Exclude: pregnancy/lactation, HIV/syphilis/CMV‑IgM/EBV, active HBV/HCV, infections, unresolved AEs, prior BCMA CAR‑T, allo‑SCT, recent auto‑SCT/therapy/steroids/vaccines, severe allergy, LVEF <50%, O2‑dependent, autoimmune disease, other malignancy, CNS mets, recent major surgery, noncompliance.
trial_source
clinical_trials.gov from Dec 2, 2025
annotation_status
manual_review_required
ai_summary
Intervention: CT0594CP, a combination of two allogeneic “universal” CAR-T cell products (UCAR-T). Types and MOA: 1) CT0594 = BCMA-UCAR-T (gene-edited allogeneic CAR-T). It recognizes B‑cell maturation antigen (BCMA) on malignant plasma cells, activating T-cell cytotoxicity. 2) CT7590 = CD94-UCAR-T (gene-edited allogeneic CAR-T). It uses a CD94-based recognition domain, designed to engage the CD94/HLA‑E axis to overcome immune evasion and augment tumor killing. Targets: BCMA+ myeloma/plasma cells, CD94/HLA‑E immune checkpoint pathway.