eligibility_summary
Eligibility: Individuals who have received a Galapagos CAR T-cell therapy in a clinical trial or Managed Access Program. Exclusions: None.
trial_source
clinical_trials.gov from Dec 2, 2025
annotation_status
manual_review_required
ai_summary
Intervention: GLPG CAR T-cell therapies—gene-modified autologous T-cell immunotherapies made with integrating lentiviral vectors to express chimeric antigen receptors, this study provides follow-up only (no new product administered). Mechanism of action: CARs bind a tumor-associated surface antigen (not specified) on hematologic cancer cells and trigger TCR-independent signaling via CD3ζ and costimulatory domains, inducing T-cell activation, clonal expansion, cytokine release, and targeted cytotoxic killing, persistence of CAR T cells is evaluated. Targets/pathways: malignant hematologic cells expressing the CAR antigen, CAR signaling pathways, T-cell effector/memory persistence, safety monitoring for replication-competent lentivirus and insertional events.