eligibility_summary
Inclusion: Signed informed consent. Exclusion: Any significant medical issue that, in the Principal Investigator’s judgment, would prevent dosing.
trial_source
clinical_trials.gov from Dec 2, 2025
annotation_status
ai
ai_summary
Intervention: GCAR1, an autologous, lentivirally transduced chimeric antigen receptor T‑cell (CAR‑T) therapy. Mechanism: the patient’s T lymphocytes are engineered to express a CAR that recognizes glycoprotein non‑metastatic B (GPNMB) on tumor cells, leading to CAR‑mediated T‑cell activation and cytotoxic killing of GPNMB‑expressing cells. Drug type: biological cell therapy (immunotherapy/CAR‑T). Targets: GPNMB‑positive alveolar soft part sarcoma cells, engages T‑cell effector pathways to attack the tumor. Single‑patient, Early Phase 1.