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eligibility_summary
Eligible participants: individuals who received CAR T cells in the DF/HCC IRB main study and can provide voluntary written informed consent, participating up to their last main study visit. Exclude anyone unable to comply with study requirements.
trial_source
clinical_trials.gov from Dec 2, 2025
annotation_status
manual_review_required
ai_summary
Trial: Long-term observational follow-up of patients previously treated with CAR T cells (from Phase 1 trials NCT05660369 and NCT06026319), no new therapy is given—only assessments (blood tests, CT/PET-CT, tumor biopsy). Drugs/interventions: Prior CAR T-cell products (autologous, gene‑modified cellular immunotherapy, gene therapy). Mechanism of action: T cells engineered with a chimeric antigen receptor that confers antibody-like recognition of a tumor antigen and activates T-cell effector functions via CD3ζ and a costimulatory domain (e.g., CD28 or 4‑1BB), leading to cytotoxic killing, cytokine release, expansion, and persistence. Targets: Malignant cells expressing the CAR antigen (antigen varies by parent trials). Pathways: CAR/TCR signaling and downstream immune/cytokine activation. Purpose: monitor delayed AEs and durability of response.