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eligibility_summary
Adults (≥18) with relapsed/refractory multiple myeloma who meet product indications and have received commercial zevor-cel infusion. Must consent to participate, if unable, consent from a legally acceptable guardian is required. No specific exclusion criteria.
trial_source
clinical_trials.gov from Dec 2, 2025
annotation_status
ai
ai_summary
Trial: Real‑world, post‑marketing, Phase IV observational study in adults with relapsed/refractory multiple myeloma. Intervention: Zevorcabtagene autoleucel (zevor‑cel), an autologous, fully human anti‑BCMA chimeric antigen receptor T‑cell therapy (gene‑modified cellular immunotherapy). Mechanism of action: Patient T cells are engineered to express a CAR that binds BCMA, antigen engagement activates CAR signaling, leading to T‑cell expansion, cytokine release, and perforin/granzyme‑mediated cytotoxicity against BCMA‑positive cells. Targets: B‑cell maturation antigen (BCMA/TNFRSF17) on malignant plasma cells, indirectly impacting the BCMA/BAFF‑APRIL survival pathway, leverages T‑cell effector pathways.