Humanized, Fc-engineered anti-CD19 IgG1 monoclonal antibody that enhances ADCC/ADCP and induces apoptosis of B cells.
Humanized, Fc-engineered anti-CD19 IgG1 monoclonal antibody that binds CD19 on B cells and enhances Fcγ receptor engagement to promote antibody-dependent cellular cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP), leading to depletion and apoptosis of CD19-positive B cells.
YES
DIRECT
The anti-CD19 IgG1 binds CD19 on B cells and its Fc engages Fcγ receptors on effector cells to trigger ADCC and ADCP, causing lysis/phagocytosis; it can also induce apoptosis of CD19+ cells.
An intravenous antibody-drug conjugate (PADCEV; ASG-22CE) consisting of a monoclonal antibody targeting NECTIN-4 linked to the cytotoxic payload monomethyl auristatin E (MMAE). After binding NECTIN-4 on tumor cells and internalization, the linker is cleaved to release MMAE, a microtubule inhibitor that disrupts tubulin, induces G2/M arrest and apoptosis, and may enable bystander killing and ADCC.
Enfortumab vedotin is a monoclonal antibody targeting NECTIN-4 linked to the cytotoxic payload MMAE. After binding NECTIN-4 and internalization, the cleavable linker releases MMAE, which inhibits microtubule polymerization, causing G2/M arrest and apoptosis; it may also enable bystander killing and ADCC.
YES
DIRECT
The ADC binds NECTIN-4 on target cells, is internalized, and releases MMAE, which inhibits microtubule polymerization causing G2/M arrest and apoptosis; may also enable bystander killing and ADCC.
An intravenous antibody-drug conjugate (PADCEV; ASG-22CE) consisting of a monoclonal antibody targeting NECTIN-4 linked to the cytotoxic payload monomethyl auristatin E (MMAE). After binding NECTIN-4 on tumor cells and internalization, the linker is cleaved to release MMAE, a microtubule inhibitor that disrupts tubulin, induces G2/M arrest and apoptosis, and may enable bystander killing and ADCC.
Enfortumab vedotin is a monoclonal antibody targeting NECTIN-4 linked to the cytotoxic payload MMAE. After binding NECTIN-4 and internalization, the cleavable linker releases MMAE, which inhibits microtubule polymerization, causing G2/M arrest and apoptosis; it may also enable bystander killing and ADCC.
NO
INDIRECT
The ADC binds NECTIN-4, is internalized, and releases MMAE, which inhibits β-tubulin polymerization causing G2/M arrest and apoptosis. β-tubulin is the intracellular payload target, not the antigen directing cell selectivity.
TROP2-directed antibody–drug conjugate (Dato-DXd) delivering a deruxtecan topoisomerase I inhibitor payload to TROP2-positive tumor cells, causing DNA damage and bystander killing.
TROP2-directed antibody–drug conjugate: a humanized anti-TROP2 monoclonal antibody linked via a cleavable peptide to deruxtecan (DXd), a topoisomerase I inhibitor. After TROP2 binding and internalization, lysosomal cleavage releases DXd, which stabilizes the Topo I–DNA complex, causing DNA breaks, inhibiting replication, and inducing apoptosis, with a bystander killing effect.
YES
DIRECT
The ADC binds TROP2 on target cells, is internalized, and lysosomal linker cleavage releases the DXd topoisomerase I inhibitor, causing DNA damage (Topo I–DNA complex stabilization), replication arrest, and apoptosis, with a bystander effect.
TROP2-directed antibody–drug conjugate (Dato-DXd) delivering a deruxtecan topoisomerase I inhibitor payload to TROP2-positive tumor cells, causing DNA damage and bystander killing.
TROP2-directed antibody–drug conjugate: a humanized anti-TROP2 monoclonal antibody linked via a cleavable peptide to deruxtecan (DXd), a topoisomerase I inhibitor. After TROP2 binding and internalization, lysosomal cleavage releases DXd, which stabilizes the Topo I–DNA complex, causing DNA breaks, inhibiting replication, and inducing apoptosis, with a bystander killing effect.
NO
INDIRECT
The ADC binds TROP2 on tumor cells, is internalized, and releases deruxtecan that inhibits topoisomerase I, causing DNA damage and apoptosis; topoisomerase I is the payload’s enzyme target, not the recognition target, so its expression alone does not trigger selective killing.