Anti-EGFR IgG1 monoclonal antibody that blocks EGFR signaling and induces antibody-dependent cellular cytotoxicity (ADCC) via CD16 on NK cells.
Chimeric IgG1 monoclonal antibody that binds the extracellular domain of EGFR, blocking ligand binding and receptor dimerization to inhibit downstream signaling (e.g., MAPK/PI3K pathways), suppressing tumor cell proliferation; its Fc engages CD16 (FcγRIIIa) on NK cells to trigger antibody-dependent cellular cytotoxicity (ADCC).
NO
INDIRECT
Cetuximab’s Fc binds CD16a on NK cells to trigger ADCC against EGFR-expressing tumor cells; CD16a-expressing cells are effectors, not targets, and are not killed by the drug.
Rabbit polyclonal anti-thymocyte globulin (polyclonal IgG) given as a single IV dose (1 mg/kg) 48–72 hours after emergence from aplasia to reinforce GVHD prophylaxis after haploidentical allo-HSCT. Binds multiple T‑cell surface antigens (e.g., CD2, CD3, CD4, CD8, HLA‑DR) leading to T‑cell depletion via complement-dependent cytotoxicity and apoptosis, with Fc-mediated clearance and immunomodulatory effects; also impacts B cells, NK cells, and dendritic cells.
Rabbit polyclonal IgG that binds multiple T‑cell surface antigens (e.g., CD2, CD3, CD4, CD8, HLA‑DR), causing T‑cell depletion via complement‑dependent cytotoxicity and apoptosis, with Fc‑mediated clearance (ADCC/ADCP) and immunomodulatory effects; also impacts B cells, NK cells, and dendritic cells to reduce alloreactivity and GVHD risk.
YES
DIRECT
Polyclonal anti-thymocyte IgG binds the CD3 complex (including CD3G) on T cells, triggering complement-dependent lysis and Fc-mediated ADCC/ADCP; cross-linking can also induce apoptosis, depleting CD3+ cells.
Rabbit polyclonal anti-thymocyte globulin (polyclonal IgG) given as a single IV dose (1 mg/kg) 48–72 hours after emergence from aplasia to reinforce GVHD prophylaxis after haploidentical allo-HSCT. Binds multiple T‑cell surface antigens (e.g., CD2, CD3, CD4, CD8, HLA‑DR) leading to T‑cell depletion via complement-dependent cytotoxicity and apoptosis, with Fc-mediated clearance and immunomodulatory effects; also impacts B cells, NK cells, and dendritic cells.
Rabbit polyclonal IgG that binds multiple T‑cell surface antigens (e.g., CD2, CD3, CD4, CD8, HLA‑DR), causing T‑cell depletion via complement‑dependent cytotoxicity and apoptosis, with Fc‑mediated clearance (ADCC/ADCP) and immunomodulatory effects; also impacts B cells, NK cells, and dendritic cells to reduce alloreactivity and GVHD risk.
YES
DIRECT
Polyclonal IgG binds CD4 on T cells and induces complement-dependent lysis and Fc-receptor–mediated ADCC/ADCP, with apoptosis, leading to depletion of CD4+ cells.
Rabbit polyclonal anti-thymocyte globulin (polyclonal IgG) given as a single IV dose (1 mg/kg) 48–72 hours after emergence from aplasia to reinforce GVHD prophylaxis after haploidentical allo-HSCT. Binds multiple T‑cell surface antigens (e.g., CD2, CD3, CD4, CD8, HLA‑DR) leading to T‑cell depletion via complement-dependent cytotoxicity and apoptosis, with Fc-mediated clearance and immunomodulatory effects; also impacts B cells, NK cells, and dendritic cells.
Rabbit polyclonal IgG that binds multiple T‑cell surface antigens (e.g., CD2, CD3, CD4, CD8, HLA‑DR), causing T‑cell depletion via complement‑dependent cytotoxicity and apoptosis, with Fc‑mediated clearance (ADCC/ADCP) and immunomodulatory effects; also impacts B cells, NK cells, and dendritic cells to reduce alloreactivity and GVHD risk.
YES
DIRECT
Binds CD8 (CD8A) on T cells and induces complement-dependent lysis and Fc-mediated effector killing (ADCC/ADCP), causing apoptosis/clearance of CD8+ cells.
Rabbit polyclonal anti-thymocyte globulin (polyclonal IgG) given as a single IV dose (1 mg/kg) 48–72 hours after emergence from aplasia to reinforce GVHD prophylaxis after haploidentical allo-HSCT. Binds multiple T‑cell surface antigens (e.g., CD2, CD3, CD4, CD8, HLA‑DR) leading to T‑cell depletion via complement-dependent cytotoxicity and apoptosis, with Fc-mediated clearance and immunomodulatory effects; also impacts B cells, NK cells, and dendritic cells.
Rabbit polyclonal IgG that binds multiple T‑cell surface antigens (e.g., CD2, CD3, CD4, CD8, HLA‑DR), causing T‑cell depletion via complement‑dependent cytotoxicity and apoptosis, with Fc‑mediated clearance (ADCC/ADCP) and immunomodulatory effects; also impacts B cells, NK cells, and dendritic cells to reduce alloreactivity and GVHD risk.
YES
DIRECT
Rabbit anti-thymocyte globulin binds CD8 (including the CD8B chain) on T cells and induces complement-dependent lysis and Fc-mediated ADCC/ADCP, with apoptosis of the target cells.