Rabbit-derived polyclonal IgG targeting human T-cell antigens; depletes T cells (and some B/NK cells) via complement-dependent cytotoxicity, ADCC, and apoptosis.
Rabbit-derived polyclonal IgG that binds multiple human T‑cell antigens and depletes T cells (with some B/NK cell effects) via complement-dependent cytotoxicity, antibody-dependent cellular cytotoxicity, and induction of apoptosis, producing profound lymphodepletion.
YES
DIRECT
Polyclonal antibodies in rATG bind CD95 (Fas) on T cells, leading to complement-dependent lysis, antibody-dependent cellular cytotoxicity, and Fas cross-linking–induced apoptosis.
Rabbit-derived polyclonal IgG targeting human T-cell antigens; depletes T cells (and some B/NK cells) via complement-dependent cytotoxicity, ADCC, and apoptosis.
Rabbit-derived polyclonal IgG that binds multiple human T‑cell antigens and depletes T cells (with some B/NK cell effects) via complement-dependent cytotoxicity, antibody-dependent cellular cytotoxicity, and induction of apoptosis, producing profound lymphodepletion.
YES
DIRECT
rATG contains antibodies that bind CD25 on T cells, leading to depletion via complement-dependent cytotoxicity and Fc-mediated ADCC, with additional apoptosis induction.
Rabbit-derived polyclonal IgG targeting human T-cell antigens; depletes T cells (and some B/NK cells) via complement-dependent cytotoxicity, ADCC, and apoptosis.
Rabbit-derived polyclonal IgG that binds multiple human T‑cell antigens and depletes T cells (with some B/NK cell effects) via complement-dependent cytotoxicity, antibody-dependent cellular cytotoxicity, and induction of apoptosis, producing profound lymphodepletion.
NO
INDIRECT
rATG binds multiple T‑cell antigens (not HLA‑DR) and depletes bound T cells via complement-dependent cytotoxicity, ADCC, and apoptosis; HLA‑DR expression alone is not directly targeted.
Rabbit-derived polyclonal IgG targeting human T-cell antigens; depletes T cells (and some B/NK cells) via complement-dependent cytotoxicity, ADCC, and apoptosis.
Rabbit-derived polyclonal IgG that binds multiple human T‑cell antigens and depletes T cells (with some B/NK cell effects) via complement-dependent cytotoxicity, antibody-dependent cellular cytotoxicity, and induction of apoptosis, producing profound lymphodepletion.
NO
INDIRECT
rATG is a polyclonal anti‑thymocyte antibody that binds multiple T‑cell antigens (not HLA class I) and depletes those cells via complement-dependent cytotoxicity, ADCC, and apoptosis; HLA class I expression alone does not make cells direct targets.
Rabbit-derived polyclonal IgG targeting human T-cell antigens; depletes T cells (and some B/NK cells) via complement-dependent cytotoxicity, ADCC, and apoptosis.
Rabbit-derived polyclonal IgG that binds multiple human T‑cell antigens and depletes T cells (with some B/NK cell effects) via complement-dependent cytotoxicity, antibody-dependent cellular cytotoxicity, and induction of apoptosis, producing profound lymphodepletion.
NO
INDIRECT
rATG recognizes multiple T‑cell antigens and depletes T cells via complement-dependent cytotoxicity, ADCC, and apoptosis; beta‑2‑microglobulin is not a defined target, so B2M+ cells are not directly targeted or killed by rATG.