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Only direct cytotoxic targets are shown
Gene
Drug Category
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Gene NCT ID Antigen/Ligand Binding Type Drug Name Drug NCI Concept Drug Category Drug Class Drug Description Drug Mechanism of Action Target Cytotoxicity Mechanism Disease Disease Type Tissue OncoTree Main Type OncoTree Name Annotation Status
CD3G NCT05902416 CD3 gamma antigen recognition Anti-thymocyte globulin CYTOTOXIC ANTIBODY Cytotoxic protein Polyclonal antibody that depletes T cells to reduce rejection and GVHD. Polyclonal anti–T-cell IgG that binds multiple T-cell surface antigens and depletes T cells via complement-dependent lysis and Fc-mediated ADCC/phagocytosis, producing immunosuppression to reduce rejection and GVHD. Anti-thymocyte globulin binds the CD3 complex (including CD3γ) on T cells and induces complement-dependent lysis and Fc receptor–mediated ADCC/phagocytosis, depleting the target cells. Myelodysplastic Syndromes CANCER Myeloid Myelodysplastic Syndromes Myelodysplastic Syndromes ai
CD4 NCT05902416 CD4 antigen recognition Anti-thymocyte globulin CYTOTOXIC ANTIBODY Cytotoxic protein Polyclonal antibody that depletes T cells to reduce rejection and GVHD. Polyclonal anti–T-cell IgG that binds multiple T-cell surface antigens and depletes T cells via complement-dependent lysis and Fc-mediated ADCC/phagocytosis, producing immunosuppression to reduce rejection and GVHD. Polyclonal antibodies bind CD4 on T cells and induce complement-dependent lysis and Fc-mediated ADCC/phagocytosis, depleting CD4+ cells. Myelodysplastic Syndromes CANCER Myeloid Myelodysplastic Syndromes Myelodysplastic Syndromes ai
CD8A NCT05902416 CD8 alpha antigen recognition Anti-thymocyte globulin CYTOTOXIC ANTIBODY Cytotoxic protein Polyclonal antibody that depletes T cells to reduce rejection and GVHD. Polyclonal anti–T-cell IgG that binds multiple T-cell surface antigens and depletes T cells via complement-dependent lysis and Fc-mediated ADCC/phagocytosis, producing immunosuppression to reduce rejection and GVHD. Polyclonal antibodies bind CD8α on T cells and trigger complement-dependent lysis and Fc-mediated ADCC/phagocytosis, depleting CD8+ cells. Myelodysplastic Syndromes CANCER Myeloid Myelodysplastic Syndromes Myelodysplastic Syndromes ai
CD5 NCT05902416 CD5 antigen recognition Anti-thymocyte globulin CYTOTOXIC ANTIBODY Cytotoxic protein Polyclonal antibody that depletes T cells to reduce rejection and GVHD. Polyclonal anti–T-cell IgG that binds multiple T-cell surface antigens and depletes T cells via complement-dependent lysis and Fc-mediated ADCC/phagocytosis, producing immunosuppression to reduce rejection and GVHD. Polyclonal IgG in ATG binds CD5 on T cells and triggers complement-dependent lysis and Fc receptor–mediated ADCC/phagocytosis, depleting the bound cells. Myelodysplastic Syndromes CANCER Myeloid Myelodysplastic Syndromes Myelodysplastic Syndromes ai
CD7 NCT05902416 CD7 antigen recognition Anti-thymocyte globulin CYTOTOXIC ANTIBODY Cytotoxic protein Polyclonal antibody that depletes T cells to reduce rejection and GVHD. Polyclonal anti–T-cell IgG that binds multiple T-cell surface antigens and depletes T cells via complement-dependent lysis and Fc-mediated ADCC/phagocytosis, producing immunosuppression to reduce rejection and GVHD. Polyclonal antibodies in ATG bind CD7 (among other T‑cell antigens) and induce complement-dependent lysis and Fc-mediated ADCC/phagocytosis, depleting CD7+ T cells. Myelodysplastic Syndromes CANCER Myeloid Myelodysplastic Syndromes Myelodysplastic Syndromes ai
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