An antibody-drug conjugate comprising a humanized anti-CD22 IgG4 monoclonal antibody linked to calicheamicin; binds CD22 on B-cell blasts, is internalized, and releases calicheamicin to induce DNA double-strand breaks and apoptosis.
Humanized anti-CD22 IgG4 monoclonal antibody linked to calicheamicin; after binding CD22 on B-cell blasts and internalization, the payload is released to bind the DNA minor groove, causing double-strand breaks and apoptosis.
ADC binds CD22, is internalized, and releases calicheamicin that binds the DNA minor groove, causing double‑strand breaks and apoptosis of the target cell.
Polyclonal antibody preparation that depletes T cells and provides immunosuppression.
Polyclonal anti-thymocyte immunoglobulin that binds multiple T-cell surface antigens and depletes T lymphocytes via complement-dependent lysis and Fc-mediated effector functions (ADCC/phagocytosis), resulting in broad immunosuppression.
Anti-thymocyte globulin binds CD2 on T cells and induces complement-dependent lysis and Fc-mediated effector killing (ADCC/phagocytosis), depleting CD2+ cells.
Polyclonal antibody preparation that depletes T cells and provides immunosuppression.
Polyclonal anti-thymocyte immunoglobulin that binds multiple T-cell surface antigens and depletes T lymphocytes via complement-dependent lysis and Fc-mediated effector functions (ADCC/phagocytosis), resulting in broad immunosuppression.
Anti-thymocyte globulin binds CD3ε on T cells and induces complement-dependent lysis and Fc-mediated ADCC/phagocytosis, depleting the target cells.
Polyclonal antibody preparation that depletes T cells and provides immunosuppression.
Polyclonal anti-thymocyte immunoglobulin that binds multiple T-cell surface antigens and depletes T lymphocytes via complement-dependent lysis and Fc-mediated effector functions (ADCC/phagocytosis), resulting in broad immunosuppression.
Anti-thymocyte globulin binds CD3 (including the CD3 delta chain) on T cells and triggers complement-dependent lysis and Fc-mediated ADCC/phagocytosis, directly depleting the targeted T cells.
Polyclonal antibody preparation that depletes T cells and provides immunosuppression.
Polyclonal anti-thymocyte immunoglobulin that binds multiple T-cell surface antigens and depletes T lymphocytes via complement-dependent lysis and Fc-mediated effector functions (ADCC/phagocytosis), resulting in broad immunosuppression.
ATG antibodies bind the CD3 complex (including CD3γ) on T cells, triggering complement-dependent lysis and Fc-mediated effector killing (ADCC/phagocytosis), leading to direct depletion of the target-expressing cells.