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Only direct cytotoxic targets are shown
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Gene NCT ID Antigen/Ligand Binding Type Drug Name Drug NCI Concept Drug Category Drug Class Drug Description Drug Mechanism of Action Target Cytotoxicity Mechanism Disease Disease Type Tissue OncoTree Main Type OncoTree Name Annotation Status
CD247 NCT06075706 CD3 zeta (CD247) antigen recognition Anti-thymocyte globulin CYTOTOXIC ANTIBODY Cytotoxic protein Polyclonal antibody preparation that depletes T cells and provides immunosuppression. Polyclonal anti-thymocyte immunoglobulin that binds multiple T-cell surface antigens and depletes T lymphocytes via complement-dependent lysis and Fc-mediated effector functions (ADCC/phagocytosis), resulting in broad immunosuppression. Anti-thymocyte globulin binds CD3 on T cells (including the CD3 complex containing CD247) and depletes them via complement-dependent lysis and Fc-mediated ADCC/phagocytosis. Steroid-refractory Acute Graft-versus-host Disease NON-CANCER Lymphoid manual_review_required
CD4 NCT06075706 CD4 antigen recognition Anti-thymocyte globulin CYTOTOXIC ANTIBODY Cytotoxic protein Polyclonal antibody preparation that depletes T cells and provides immunosuppression. Polyclonal anti-thymocyte immunoglobulin that binds multiple T-cell surface antigens and depletes T lymphocytes via complement-dependent lysis and Fc-mediated effector functions (ADCC/phagocytosis), resulting in broad immunosuppression. Anti-thymocyte globulin binds CD4 on T cells and induces complement-dependent lysis and Fc-mediated ADCC/phagocytosis, depleting CD4+ cells. Steroid-refractory Acute Graft-versus-host Disease NON-CANCER Lymphoid manual_review_required
CD8A NCT06075706 CD8 alpha antigen recognition Anti-thymocyte globulin CYTOTOXIC ANTIBODY Cytotoxic protein Polyclonal antibody preparation that depletes T cells and provides immunosuppression. Polyclonal anti-thymocyte immunoglobulin that binds multiple T-cell surface antigens and depletes T lymphocytes via complement-dependent lysis and Fc-mediated effector functions (ADCC/phagocytosis), resulting in broad immunosuppression. Antibodies in anti-thymocyte globulin bind CD8α on T cells and induce complement-dependent lysis and Fc-mediated ADCC/phagocytosis, depleting CD8+ cells. Steroid-refractory Acute Graft-versus-host Disease NON-CANCER Lymphoid manual_review_required
IL2RA NCT06075706 IL-2 receptor alpha (CD25) antigen recognition Anti-thymocyte globulin CYTOTOXIC ANTIBODY Cytotoxic protein Polyclonal antibody preparation that depletes T cells and provides immunosuppression. Polyclonal anti-thymocyte immunoglobulin that binds multiple T-cell surface antigens and depletes T lymphocytes via complement-dependent lysis and Fc-mediated effector functions (ADCC/phagocytosis), resulting in broad immunosuppression. Polyclonal antibodies in ATG bind CD25 on T cells and trigger complement-dependent lysis and Fc-mediated ADCC/phagocytosis, depleting CD25+ cells. Steroid-refractory Acute Graft-versus-host Disease NON-CANCER Lymphoid manual_review_required
CD28 NCT06075706 CD28 antigen recognition Anti-thymocyte globulin CYTOTOXIC ANTIBODY Cytotoxic protein Polyclonal antibody preparation that depletes T cells and provides immunosuppression. Polyclonal anti-thymocyte immunoglobulin that binds multiple T-cell surface antigens and depletes T lymphocytes via complement-dependent lysis and Fc-mediated effector functions (ADCC/phagocytosis), resulting in broad immunosuppression. Anti-thymocyte globulin binds CD28 on T cells and triggers complement-dependent lysis and Fc receptor–mediated ADCC/phagocytosis, depleting the bound cells. Steroid-refractory Acute Graft-versus-host Disease NON-CANCER Lymphoid manual_review_required
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