Rabbit polyclonal anti-thymocyte globulin (polyclonal IgG) given as a single IV dose (1 mg/kg) 48–72 hours after emergence from aplasia to reinforce GVHD prophylaxis after haploidentical allo-HSCT. Binds multiple T‑cell surface antigens (e.g., CD2, CD3, CD4, CD8, HLA‑DR) leading to T‑cell depletion via complement-dependent cytotoxicity and apoptosis, with Fc-mediated clearance and immunomodulatory effects; also impacts B cells, NK cells, and dendritic cells.
Rabbit polyclonal IgG that binds multiple T‑cell surface antigens (e.g., CD2, CD3, CD4, CD8, HLA‑DR), causing T‑cell depletion via complement‑dependent cytotoxicity and apoptosis, with Fc‑mediated clearance (ADCC/ADCP) and immunomodulatory effects; also impacts B cells, NK cells, and dendritic cells to reduce alloreactivity and GVHD risk.
Polyclonal anti-thymocyte IgG binds the CD3 complex (including CD3G) on T cells, triggering complement-dependent lysis and Fc-mediated ADCC/ADCP; cross-linking can also induce apoptosis, depleting CD3+ cells.
Rabbit polyclonal anti-thymocyte globulin (polyclonal IgG) given as a single IV dose (1 mg/kg) 48–72 hours after emergence from aplasia to reinforce GVHD prophylaxis after haploidentical allo-HSCT. Binds multiple T‑cell surface antigens (e.g., CD2, CD3, CD4, CD8, HLA‑DR) leading to T‑cell depletion via complement-dependent cytotoxicity and apoptosis, with Fc-mediated clearance and immunomodulatory effects; also impacts B cells, NK cells, and dendritic cells.
Rabbit polyclonal IgG that binds multiple T‑cell surface antigens (e.g., CD2, CD3, CD4, CD8, HLA‑DR), causing T‑cell depletion via complement‑dependent cytotoxicity and apoptosis, with Fc‑mediated clearance (ADCC/ADCP) and immunomodulatory effects; also impacts B cells, NK cells, and dendritic cells to reduce alloreactivity and GVHD risk.
Polyclonal IgG binds CD4 on T cells and induces complement-dependent lysis and Fc-receptor–mediated ADCC/ADCP, with apoptosis, leading to depletion of CD4+ cells.
Rabbit polyclonal anti-thymocyte globulin (polyclonal IgG) given as a single IV dose (1 mg/kg) 48–72 hours after emergence from aplasia to reinforce GVHD prophylaxis after haploidentical allo-HSCT. Binds multiple T‑cell surface antigens (e.g., CD2, CD3, CD4, CD8, HLA‑DR) leading to T‑cell depletion via complement-dependent cytotoxicity and apoptosis, with Fc-mediated clearance and immunomodulatory effects; also impacts B cells, NK cells, and dendritic cells.
Rabbit polyclonal IgG that binds multiple T‑cell surface antigens (e.g., CD2, CD3, CD4, CD8, HLA‑DR), causing T‑cell depletion via complement‑dependent cytotoxicity and apoptosis, with Fc‑mediated clearance (ADCC/ADCP) and immunomodulatory effects; also impacts B cells, NK cells, and dendritic cells to reduce alloreactivity and GVHD risk.
Binds CD8 (CD8A) on T cells and induces complement-dependent lysis and Fc-mediated effector killing (ADCC/ADCP), causing apoptosis/clearance of CD8+ cells.
Rabbit polyclonal anti-thymocyte globulin (polyclonal IgG) given as a single IV dose (1 mg/kg) 48–72 hours after emergence from aplasia to reinforce GVHD prophylaxis after haploidentical allo-HSCT. Binds multiple T‑cell surface antigens (e.g., CD2, CD3, CD4, CD8, HLA‑DR) leading to T‑cell depletion via complement-dependent cytotoxicity and apoptosis, with Fc-mediated clearance and immunomodulatory effects; also impacts B cells, NK cells, and dendritic cells.
Rabbit polyclonal IgG that binds multiple T‑cell surface antigens (e.g., CD2, CD3, CD4, CD8, HLA‑DR), causing T‑cell depletion via complement‑dependent cytotoxicity and apoptosis, with Fc‑mediated clearance (ADCC/ADCP) and immunomodulatory effects; also impacts B cells, NK cells, and dendritic cells to reduce alloreactivity and GVHD risk.
Rabbit anti-thymocyte globulin binds CD8 (including the CD8B chain) on T cells and induces complement-dependent lysis and Fc-mediated ADCC/ADCP, with apoptosis of the target cells.
Rabbit polyclonal anti-thymocyte globulin (polyclonal IgG) given as a single IV dose (1 mg/kg) 48–72 hours after emergence from aplasia to reinforce GVHD prophylaxis after haploidentical allo-HSCT. Binds multiple T‑cell surface antigens (e.g., CD2, CD3, CD4, CD8, HLA‑DR) leading to T‑cell depletion via complement-dependent cytotoxicity and apoptosis, with Fc-mediated clearance and immunomodulatory effects; also impacts B cells, NK cells, and dendritic cells.
Rabbit polyclonal IgG that binds multiple T‑cell surface antigens (e.g., CD2, CD3, CD4, CD8, HLA‑DR), causing T‑cell depletion via complement‑dependent cytotoxicity and apoptosis, with Fc‑mediated clearance (ADCC/ADCP) and immunomodulatory effects; also impacts B cells, NK cells, and dendritic cells to reduce alloreactivity and GVHD risk.
Rabbit polyclonal IgG binds HLA‑DR (including HLA‑DRA) on cells and triggers complement-dependent cytotoxicity plus Fc-mediated ADCC/ADCP, and can induce apoptosis.