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Only direct cytotoxic targets are shown
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Gene NCT ID Antigen/Ligand Binding Type Drug Name Drug NCI Concept Drug Category Drug Class Drug Description Drug Mechanism of Action Target Cytotoxicity Mechanism Disease Disease Type Tissue OncoTree Main Type OncoTree Name Annotation Status
CD7 NCT06316427 CD7 antigen recognition Autologous CD7 CAR T-cell CAR T Cellular Therapy Patient-derived T cells engineered to express a chimeric antigen receptor targeting CD7; CAR engagement activates T-cell effector functions (TCR-like signaling, perforin/granzyme release, cytokine secretion) to kill CD7+ malignant T cells. Expected on-target effects include depletion of normal CD7+ T cells and some NK cells, leading to T-cell aplasia. Autologous T cells are genetically engineered to express a chimeric antigen receptor targeting CD7. CAR engagement triggers TCR-like signaling and costimulation, inducing cytotoxicity (perforin/granzyme) and cytokine release to eliminate CD7+ malignant T cells; expected on‑target effects include depletion of normal CD7+ T cells and some NK cells (T‑cell aplasia). CD7 CAR T cells bind CD7 on target cells, become activated, and kill via perforin/granzyme-mediated cytolysis and apoptosis (with possible Fas/FasL and cytokine-mediated effects). T-cell Malignancies CANCER Lymphoid T-Lymphoblastic Leukemia/Lymphoma T-Lymphoblastic Leukemia/Lymphoma ai
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