Polyclonal anti–T-cell antibody that depletes recipient lymphocytes to facilitate donor cell engraftment.
Polyclonal anti-thymocyte IgG that binds multiple T-cell surface antigens and depletes lymphocytes via complement-dependent cytotoxicity, antibody-dependent cellular cytotoxicity, and apoptosis, leading to profound T-cell immunosuppression to facilitate donor cell engraftment.
rATG contains antibodies that bind CD2 on T cells and trigger complement-dependent lysis and Fc-mediated ADCC, and can directly induce apoptosis, depleting CD2+ cells.
Polyclonal anti–T-cell antibody that depletes recipient lymphocytes to facilitate donor cell engraftment.
Polyclonal anti-thymocyte IgG that binds multiple T-cell surface antigens and depletes lymphocytes via complement-dependent cytotoxicity, antibody-dependent cellular cytotoxicity, and apoptosis, leading to profound T-cell immunosuppression to facilitate donor cell engraftment.
rATG binds CD3 on T cells; its Fc triggers complement-dependent lysis and ADCC and can induce apoptosis, directly depleting CD3E+ T cells.
Polyclonal anti–T-cell antibody that depletes recipient lymphocytes to facilitate donor cell engraftment.
Polyclonal anti-thymocyte IgG that binds multiple T-cell surface antigens and depletes lymphocytes via complement-dependent cytotoxicity, antibody-dependent cellular cytotoxicity, and apoptosis, leading to profound T-cell immunosuppression to facilitate donor cell engraftment.
rATG contains antibodies that bind CD4 on T cells and deplete them via complement-dependent cytotoxicity and Fc-mediated ADCC/phagocytosis, inducing apoptosis and lysis of CD4+ cells.
Polyclonal anti–T-cell antibody that depletes recipient lymphocytes to facilitate donor cell engraftment.
Polyclonal anti-thymocyte IgG that binds multiple T-cell surface antigens and depletes lymphocytes via complement-dependent cytotoxicity, antibody-dependent cellular cytotoxicity, and apoptosis, leading to profound T-cell immunosuppression to facilitate donor cell engraftment.
rATG contains antibodies that bind T‑cell antigens including CD8; bound cells are eliminated via complement-dependent cytotoxicity and Fc-mediated ADCC, with induction of apoptosis, depleting CD8+ T cells.
Polyclonal anti–T-cell antibody that depletes recipient lymphocytes to facilitate donor cell engraftment.
Polyclonal anti-thymocyte IgG that binds multiple T-cell surface antigens and depletes lymphocytes via complement-dependent cytotoxicity, antibody-dependent cellular cytotoxicity, and apoptosis, leading to profound T-cell immunosuppression to facilitate donor cell engraftment.
rATG binds CD5 on lymphocytes and triggers complement-dependent lysis and Fc receptor–mediated ADCC/apoptosis, leading to depletion of CD5+ cells.