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Gene

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antigen recognition (3404)

other (145)

receptor ligand recognition (192)

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ai (3167)

manual_review_required (574)

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CANCER (2959)

NON-CANCER (780)

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Gene	NCT ID	Antigen/Ligand	Binding Type	Drug Name	Drug Category	Drug Class	Drug Description	Drug Mechanism of Action	Target Cytotoxicity Mechanism	Disease	Disease Type	Tissue	Annotation Status
CD247	NCT05669001	CD3 zeta (TCR signaling chain)	antigen recognition	ATG (antithymocyte globulin)	CYTOTOXIC ANTIBODY	Inhibitor	Polyclonal antilymphocyte/antithymocyte globulin that depletes T cells.	Polyclonal anti–T-lymphocyte immunoglobulin that binds multiple T‑cell surface antigens and induces complement-dependent cytotoxicity and Fc-mediated clearance (ADCC/phagocytosis), leading to rapid T‑cell depletion and immunosuppression.	ATG antibodies bind the TCR–CD3 complex on T cells (including the CD3 zeta–containing complex), triggering complement-dependent lysis and Fc-mediated ADCC/phagocytosis, leading to direct T-cell depletion.	Renal Transplantation	NON-CANCER	Kidney	manual_review_required
CD4	NCT05669001	CD4	antigen recognition	ATG (antithymocyte globulin)	CYTOTOXIC ANTIBODY	Inhibitor	Polyclonal antilymphocyte/antithymocyte globulin that depletes T cells.	Polyclonal anti–T-lymphocyte immunoglobulin that binds multiple T‑cell surface antigens and induces complement-dependent cytotoxicity and Fc-mediated clearance (ADCC/phagocytosis), leading to rapid T‑cell depletion and immunosuppression.	ATG antibodies bind CD4 on T cells and trigger complement-dependent lysis and Fc-mediated ADCC/phagocytic clearance, depleting CD4+ cells.	Renal Transplantation	NON-CANCER	Kidney	manual_review_required
CD8A	NCT05669001	CD8 alpha	antigen recognition	ATG (antithymocyte globulin)	CYTOTOXIC ANTIBODY	Inhibitor	Polyclonal antilymphocyte/antithymocyte globulin that depletes T cells.	Polyclonal anti–T-lymphocyte immunoglobulin that binds multiple T‑cell surface antigens and induces complement-dependent cytotoxicity and Fc-mediated clearance (ADCC/phagocytosis), leading to rapid T‑cell depletion and immunosuppression.	ATG antibodies bind CD8α on T cells and induce complement-dependent lysis and Fc-mediated ADCC/phagocytic clearance, depleting the CD8+ T cells.	Renal Transplantation	NON-CANCER	Kidney	manual_review_required
IL2RA	NCT05669001	IL-2 receptor alpha (CD25)	antigen recognition	ATG (antithymocyte globulin)	CYTOTOXIC ANTIBODY	Inhibitor	Polyclonal antilymphocyte/antithymocyte globulin that depletes T cells.	Polyclonal anti–T-lymphocyte immunoglobulin that binds multiple T‑cell surface antigens and induces complement-dependent cytotoxicity and Fc-mediated clearance (ADCC/phagocytosis), leading to rapid T‑cell depletion and immunosuppression.	ATG antibodies bind CD25 on T cells, triggering complement-dependent lysis and Fc-mediated effector functions (ADCC/phagocytosis) that deplete the bound cells.	Renal Transplantation	NON-CANCER	Kidney	manual_review_required
ITGAL	NCT05669001	LFA-1 alpha chain (CD11a)	antigen recognition	ATG (antithymocyte globulin)	CYTOTOXIC ANTIBODY	Inhibitor	Polyclonal antilymphocyte/antithymocyte globulin that depletes T cells.	Polyclonal anti–T-lymphocyte immunoglobulin that binds multiple T‑cell surface antigens and induces complement-dependent cytotoxicity and Fc-mediated clearance (ADCC/phagocytosis), leading to rapid T‑cell depletion and immunosuppression.	ATG contains antibodies that bind CD11a (LFA-1) on T cells, triggering complement-dependent lysis and Fc receptor–mediated ADCC/phagocytosis, leading to direct depletion of target-expressing cells.	Renal Transplantation	NON-CANCER	Kidney	manual_review_required