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Gene NCT ID Antigen/Ligand Binding Type Drug Name Drug NCI Concept Drug Category Drug Class Drug Description Drug Mechanism of Action Target Cytotoxicity Mechanism Disease Disease Type Tissue OncoTree Main Type OncoTree Name Annotation Status
ULBP2 NCT03735589 ULBP2 receptor ligand recognition Autologous Natural Killer Cell-like Cytotoxic T Lymphocytes (nCTLs) TCR SELECTED T CELLS Unedited cells Autologous ex vivo dendritic cell-sensitized cytotoxic T lymphocytes with NK-like cytotoxic features, administered intraperitoneally to kill residual peritoneal tumor cells. Autologous cytotoxic T lymphocytes expanded ex vivo by dendritic cell sensitization to enrich native TCR tumor specificity; upon intraperitoneal infusion, they kill residual peritoneal tumor cells via antigen-specific TCR recognition and perforin/granzyme release, augmented by NK-like cytotoxic pathways (e.g., NKG2D-mediated killing). nCTLs express NKG2D; engagement of ULBP2 on target cells activates cytotoxic degranulation (perforin/granzyme) leading to target cell death. Stage IVB Primary Peritoneal Cancer AJCC v8 CANCER Peritoneum Peritoneal Cancer Peritoneal Serous Carcinoma manual_review_required
ULBP3 NCT03735589 ULBP3 receptor ligand recognition Autologous Natural Killer Cell-like Cytotoxic T Lymphocytes (nCTLs) TCR SELECTED T CELLS Unedited cells Autologous ex vivo dendritic cell-sensitized cytotoxic T lymphocytes with NK-like cytotoxic features, administered intraperitoneally to kill residual peritoneal tumor cells. Autologous cytotoxic T lymphocytes expanded ex vivo by dendritic cell sensitization to enrich native TCR tumor specificity; upon intraperitoneal infusion, they kill residual peritoneal tumor cells via antigen-specific TCR recognition and perforin/granzyme release, augmented by NK-like cytotoxic pathways (e.g., NKG2D-mediated killing). nCTLs use their NKG2D receptor to bind ULBP3 on target cells, triggering degranulation with perforin/granzymes and inducing apoptosis/lysis. Stage IVB Primary Peritoneal Cancer AJCC v8 CANCER Peritoneum Peritoneal Cancer Peritoneal Serous Carcinoma manual_review_required
RAET1E NCT03735589 ULBP4 (RAET1E) receptor ligand recognition Autologous Natural Killer Cell-like Cytotoxic T Lymphocytes (nCTLs) TCR SELECTED T CELLS Unedited cells Autologous ex vivo dendritic cell-sensitized cytotoxic T lymphocytes with NK-like cytotoxic features, administered intraperitoneally to kill residual peritoneal tumor cells. Autologous cytotoxic T lymphocytes expanded ex vivo by dendritic cell sensitization to enrich native TCR tumor specificity; upon intraperitoneal infusion, they kill residual peritoneal tumor cells via antigen-specific TCR recognition and perforin/granzyme release, augmented by NK-like cytotoxic pathways (e.g., NKG2D-mediated killing). nCTLs use NKG2D to recognize ULBP4 on target cells, triggering cytotoxic degranulation (perforin/granzyme) and killing the target cell. Stage IVB Primary Peritoneal Cancer AJCC v8 CANCER Peritoneum Peritoneal Cancer Peritoneal Serous Carcinoma manual_review_required
RAET1G NCT03735589 ULBP5 (RAET1G) receptor ligand recognition Autologous Natural Killer Cell-like Cytotoxic T Lymphocytes (nCTLs) TCR SELECTED T CELLS Unedited cells Autologous ex vivo dendritic cell-sensitized cytotoxic T lymphocytes with NK-like cytotoxic features, administered intraperitoneally to kill residual peritoneal tumor cells. Autologous cytotoxic T lymphocytes expanded ex vivo by dendritic cell sensitization to enrich native TCR tumor specificity; upon intraperitoneal infusion, they kill residual peritoneal tumor cells via antigen-specific TCR recognition and perforin/granzyme release, augmented by NK-like cytotoxic pathways (e.g., NKG2D-mediated killing). Infused nCTLs express NKG2D; engagement of ULBP5 (RAET1G) on target cells activates them to release perforin/granzymes, causing apoptosis of the target cell. Stage IVB Primary Peritoneal Cancer AJCC v8 CANCER Peritoneum Peritoneal Cancer Peritoneal Serous Carcinoma manual_review_required
RAET1L NCT03735589 ULBP6 (RAET1L) receptor ligand recognition Autologous Natural Killer Cell-like Cytotoxic T Lymphocytes (nCTLs) TCR SELECTED T CELLS Unedited cells Autologous ex vivo dendritic cell-sensitized cytotoxic T lymphocytes with NK-like cytotoxic features, administered intraperitoneally to kill residual peritoneal tumor cells. Autologous cytotoxic T lymphocytes expanded ex vivo by dendritic cell sensitization to enrich native TCR tumor specificity; upon intraperitoneal infusion, they kill residual peritoneal tumor cells via antigen-specific TCR recognition and perforin/granzyme release, augmented by NK-like cytotoxic pathways (e.g., NKG2D-mediated killing). nCTLs express NKG2D; engagement of ULBP6 (RAET1L) on target cells activates cytotoxic degranulation (perforin/granzyme), leading to direct lysis. Stage IVB Primary Peritoneal Cancer AJCC v8 CANCER Peritoneum Peritoneal Cancer Peritoneal Serous Carcinoma manual_review_required
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