gene_symbol
TOP1
hgnc_id
HGNC:11986
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The ADC targets TROP2 (not Topoisomerase I), is internalized, and releases a topoisomerase I inhibitor that induces DNA damage and apoptosis; Topoisomerase I expression alone is not sufficient for targeting or killing.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Intracellular payload target
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06469944
disease_id_num_tar_ref
1141
drug_id_num_tar_ref
3120