gene_symbol
CD47
hgnc_id
HGNC:1682
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Blocks the CD47–SIRPα ‘don’t‑eat‑me’ signal and opsonizes CD47+ cells; macrophages engage the antibody Fc via Fcγ receptors and directly phagocytose/kill the target cells (ADCP).
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Blocks CD47-SIRPA interaction to enable macrophage phagocytosis
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05807126
disease_id_num_tar_ref
1173
drug_id_num_tar_ref
3207