gene_symbol
HLA-B
hgnc_id
HGNC:4932
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Adoptively transferred tumor-reactive T cells recognize the tumor antigen peptide–HLA-B complex via their native TCR and kill targets via perforin/granzyme cytolysis (and Fas–FasL apoptosis).
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
CD8+ TCR recognition; peptide sequence varies by patient/tumor and may include neoantigens or shared tumor-associated antigens
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06121570
disease_id_num_tar_ref
1195
drug_id_num_tar_ref
3267