gene_symbol
HLA-C
hgnc_id
HGNC:4933
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Adoptively transferred T cells recognize the tumor peptide–HLA-C complex via native TCRs and kill targets through perforin/granzyme-mediated apoptosis (with possible Fas–FasL/cytokine contributions).
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
CD8+ TCR recognition; peptide sequence varies by patient/tumor and may include neoantigens or shared tumor-associated antigens
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06121570
disease_id_num_tar_ref
1195
drug_id_num_tar_ref
3267