gene_symbol
HLA-DPB1
hgnc_id
HGNC:4940
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Native TCRs on the infused lymphocytes recognize the tumor antigen peptide–HLA-DP complex and directly kill target cells via perforin/granzyme-mediated cytolysis (and related T-cell cytotoxic pathways).
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
CD4+ TCR recognition on tumor cells or APCs; peptide sequence varies by patient/tumor and may include neoantigens or shared tumor-associated antigens
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06121570
disease_id_num_tar_ref
1195
drug_id_num_tar_ref
3267