gene_symbol
HLA-DQB1
hgnc_id
HGNC:4944
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Native TCRs on reinfused tumor-reactive T cells recognize the tumor antigen peptide–HLA-DQ complex and kill the presenting cell via perforin/granzyme (and Fas–FasL) cytotoxicity.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
CD4+ TCR recognition on tumor cells or APCs; peptide sequence varies by patient/tumor and may include neoantigens or shared tumor-associated antigens
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06121570
disease_id_num_tar_ref
1195
drug_id_num_tar_ref
3267