gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The ADC binds HER2, is internalized, and the cleavable linker releases MMAE, which disrupts microtubules causing mitotic arrest and apoptosis; the IgG1 Fc can also induce ADCC.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
ADC antibody component targets cell-surface receptor
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06660511
disease_id_num_tar_ref
1199
drug_id_num_tar_ref
3274