gene_symbol
TUBB
hgnc_id
HGNC:20778
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The ADC targets HER2, is internalized, and releases MMAE, which binds beta-tubulin to disrupt microtubules causing mitotic arrest and apoptosis; beta-tubulin is not the antibody-recognized target.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
MMAE payload binds vinca site to inhibit microtubule polymerization
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06660511
disease_id_num_tar_ref
1199
drug_id_num_tar_ref
3274