gene_symbol
KIT
hgnc_id
HGNC:6342
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Blocks SCF–KIT survival signaling on KIT+ mast cells, leading to apoptosis and depletion; Fc effector functions may also contribute via ADCC/ADCP against KIT-expressing cells.
enzyme_product
On
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Receptor tyrosine kinase; blocks SCF binding and KIT signaling
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05774184
disease_id_num_tar_ref
1209
drug_id_num_tar_ref
3296