gene_symbol
EGFR
hgnc_id
HGNC:3236
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The anti-EGFR IgG binds EGFR on target cells and engages Fcγ receptors on immune effectors to trigger antibody-dependent cell-mediated cytotoxicity (ADCC; possibly CDC), leading to killing of EGFR-expressing cells.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Blocks ligand binding and receptor dimerization; inhibitory antibody
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05360368
disease_id_num_tar_ref
1214
drug_id_num_tar_ref
3305