gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
ARX788 binds HER2, is internalized, and releases an MMAF analog that inhibits microtubule polymerization, causing G2/M arrest and apoptosis; the antibody may also recruit ADCC.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06663748
disease_id_num_tar_ref
136
drug_id_num_tar_ref
369