gene_symbol
TUBB
hgnc_id
HGNC:20778
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
ARX788 targets HER2 on the cell surface, is internalized, and then releases an auristatin payload that binds beta-tubulin to block microtubule polymerization, causing G2/M arrest and apoptosis; beta-tubulin is not the directly targeted antigen.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Auristatin (MMAF analog; Amberstatin-269/opadotin) payload binds vinca site to inhibit polymerization
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06663748
disease_id_num_tar_ref
136
drug_id_num_tar_ref
369