gene_symbol
FCGR3A
hgnc_id
HGNC:3619
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
ARX788 targets HER2, not CD16a. It kills HER2+ cells via internalization and release of an MMAF payload that inhibits microtubules; its Fc can engage CD16a on NK cells to drive ADCC against HER2+ cells. CD16a+ cells are effectors, not targets.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Fc-mediated ADCC engagement by IgG Fc
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06663748
disease_id_num_tar_ref
136
drug_id_num_tar_ref
369