gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
HER2-directed CAR-T cells bind HER2 on target cells, activating CD3zeta/costimulatory signaling and inducing T-cell cytotoxicity via perforin/granzyme-mediated lysis (and death receptor pathways), MHC-independent.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds the extracellular domain of HER2 on tumor cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06515626
disease_id_num_tar_ref
1252
drug_id_num_tar_ref
3389