gene_symbol
KRAS
hgnc_id
HGNC:6407
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The mRNA vaccine primes and expands KRAS-mutant–specific CD8+ T cells, which recognize KRAS neoantigen peptides presented on MHC and kill tumor cells via perforin/granzyme-mediated cytotoxicity.
enzyme_product
On
epitope
On
variant
On
isoform
Off
hla_specific
On
gated
Off
other_modifier
Presented by HLA class I and II on APCs for TCR recognition
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06577532
disease_id_num_tar_ref
143
drug_id_num_tar_ref
385