gene_symbol
CD276
hgnc_id
HGNC:19137
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
ADC binds B7-H3, is internalized, and releases a duocarmycin payload that alkylates DNA, killing the cell; IgG1 Fc can also mediate ADCC/CDC (plus bystander effect).
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
cell-surface immunomodulatory antigen
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05551117
disease_id_num_tar_ref
1362
drug_id_num_tar_ref
3694