gene_symbol
UNKNOWN
binding_type
other
cytotoxicity
YES
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
After the ADC binds B7‑H3 and is internalized, its duocarmycin payload is released and alkylates the DNA minor groove, causing DNA damage and tumor cell death; Fc effector/bystander effects may contribute.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
duocarmycin payload; minor-groove alkylation
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05551117
disease_id_num_tar_ref
1362
drug_id_num_tar_ref
3694